background:   after cervical discectomy, autogenetic bone is packed into the cage to increase the rate of :union: between adjacent vertebral bodies, but donor site–related complications can still occur. in this study we evaluate the use   of hydroxyapatite granules as a substitute for autograft for interbody fusion.     methods:   from november 2008 to november 2011, 236 patients participated i...

This study evaluates the cytotoxic and mutagenic effect of synthetic hydroxyapatite granules (source: School of Material and Mineral Resources Engineering, Universiti Sains Malaysia) in the bone marrow cells of mice. Mice are exposed to synthetic hydroxyapatite granules, the bone marrow cells are collected and observed for chromosome aberrations. No chromosome aberrations were noticed in the an...

In this work, hydroxyapatite/silica nanopowders were granulated to fabricate plasma sprayable feedstocks. For this purpose, the wet powders obtained by heating a hydroxyapatite/silica slurry were stirred and sieved. To realize the feedstock application in the plasma spray process, powders were deposited on titanium substrate. The morphology of granulated feedstock and sprayed coating was ...

The spherical porous granules of octacalcium phosphate (OCP) and hydroxyapatite (HA) have the potential for applications in scaffolds bone regeneration. alpha-tricalcium were immersed a pH 5.0 buffer solution that contained 0.1 mM ascorbic acid (AscP), an osteogenesis-promoting drug, at 60 °C. This resulted fabrication AscP-loaded HA/OCP granules. OCP HA phases concentrated surface interior gra...

Background:   After cervical discectomy, autogenetic bone is packed into the cage to increase the rate of union between adjacent vertebral bodies, but donor site–related complications can still occur. In this study we evaluate the use   of hydroxyapatite granules as a substitute for autograft for interbody fusion.     Methods:   From November 2008 to November 2011, 236 patients participated in ...

The use of porous blocks is limited, however, because hydroxyapatite has only modest tensile strength and a low fracture toughness, leaving it susceptible to fracture or fragmentation if subjected to mechanical loading. Incorporating hydroxyapatite granules into a biocompatible polymeric matrix produces a more robust material. Judicious selection of the loading level of the HA allows for a high...

Suspensions of nanoparticles (SiO2, SiC, TiO2, CNT, Nanoclay and Hydroxyapatite) were spray dried to produce dry granulated products. The nanoparticles were consolidated in granules making them more convenient and safer to use in further processing compared to handling of nanopowders.

Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, s...